AOD9604 is a fragment of the growth hormone molecule (amino acids 177–191) that retains lipolytic properties but does not activate the growth hormone receptor or drive tissue growth or cell proliferation. In preclinical obesity models in mice, it enhanced fat oxidation and raised plasma glycerol as a direct index of lipolysis, reducing body mass without affecting glucose levels or insulin secretion—unlike full growth hormone. The molecule does not compete for its receptor and does not activate IGF-1–dependent pathways, making it a metabolically "clean" tool without typical risks of exogenous GH.
The clinical program included six studies with various routes of administration, including two phase IIb trials in 300 and 500 adults with obesity. In all studies, AOD9604 showed good tolerability and no serious adverse events at oral doses from 1 to 54 mg per day. In phase IIb, body weight loss was approximately 2 kg beyond placebo over 12 weeks with improved lipid profile. Additional safety confirmation is GRAS (Generally Recognized As Safe) status assigned by the US regulator for use in food supplements—a rare level of confirmation for a molecule of this class.
AOD9604 is most appropriate for a scenario of gentle, sustained deficit where good tolerability and absence of hormonal risks matter more than maximum speed of weight loss. It is not a replacement for incretin strategies in effect strength, but it is one of the few metabolic tools with a full clinical safety program.
🔥 Lipolysis and fat oxidation (preclinical): ★★★★☆
⚖️ Weight-loss potential (clinically moderate): ★★☆☆
🍬 Glucose and insulin (vs. growth hormone): ★★★★☆
✅ Safety and tolerability (clinical program): ★★★★☆
⚠️ Possible sensations and side effects: usually mild; individual reactions possible
🤝 Combinations (goal → stack)
⚖️ Weight + appetite control → AOD9604 + Cagrilintide
🏁 Recomposition → AOD9604 + 5-Amino-1MQ
🔧 Deficit + tissue recovery → AOD9604 + BPC-157
| CAS number | 221231-10-3 |
| Batch purity | 99.88 % |
Full information in our guide
https://peptideboost.club/guide/aod-9604
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