ARA-290 is an eleven–amino acid fragment of erythropoietin devoid of the ability to stimulate red blood cell production. It was developed as a tool for tissue protection and repair through activation of the innate repair receptor—a complex of the erythropoietin receptor subunit and the common beta subunit shared by several cytokine receptors. Activation of this complex triggers anti-inflammatory signals, suppresses pro-inflammatory mediators, protects cells from apoptosis, and stimulates restoration of tissue structure.
In a randomized, double-blind, placebo-controlled trial in patients with sarcoidosis and small-fiber neuropathy, daily subcutaneous injections for 28 days led to significant improvement in neuropathy symptoms on validated scales, with reduced pain, burning, and discomfort. A critically important finding: concurrently, an objective marker was recorded—a 20–30% increase in small corneal nerve fiber density, confirming structural recovery of neural tissue, not merely subjective relief. No serious adverse events occurred during the study period.
It should be noted that the clinical trial was conducted in patients with sarcoidosis—a specific autoimmune condition. This does not limit the molecule’s potential, but it sets context honestly: data were obtained in a defined population, and transfer of the profile to other neuropathies is mechanistically justified, though large direct trials in other indications remain limited to date.
🧠 Neuropathy and small nerve fibers (clinical): ★★★★☆
🔥 Anti-inflammatory background: ★★★★☆
🔧 Repair and cytoprotection: ★★★★☆
✅ Safety: ★★★★☆ (strong profile for the research track)
⚠️ Possible sensations and side effects: generally mild; individual
🤝 Combinations (goal → stack)
🧠 Neuro-recovery → ARA-290 + BPC-157
😌 Neuro-comfort → ARA-290 + Selank
🌙 Rhythm and sleep + recovery → ARA-290 + Epitalon
| CAS number | 1208243-50-8 |
| Batch purity | 99.15 % |
Full information in our guide
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