ATX-304 (formerly O304) is a direct pan-activator of AMP-activated protein kinase (AMPK), exerting its effect simultaneously in multiple tissues: skeletal muscle, liver, adipose tissue, and cardiovascular tissue. AMPK is the cellular "energy sensor": when the AMP/ATP ratio rises (the cell experiences energy deficit), AMPK switches on catabolic programsβincreased fat oxidation, glucose uptake, mitochondrial biogenesisβand simultaneously suppresses anabolic expenditure (lipid and cholesterol synthesis). ATX-304 mimics this signal without true energy deficit, differing from metformin (indirect AMPK activator) in potency and specificity of action.
Β
In the liver, ATX-304 shifts the metabolic program from lipogenesis to Ξ²-oxidation: it lowers FASN and ACACA (fatty acid synthesis enzymes) toward healthy control levels while increasing fat oxidation and cholesterol transport into bile. In NAFLD/NASH models this manifested as significant reduction of steatosis, suppression of fibrosis progression, and normalization of cholesterol. Additionally, in a cisplatin acute kidney injury model, ATX-304 protected renal tubular cells through AMPK-dependent metabolic reprogramming: reduced oxidative stress and inflammation while preserving organ function. In clinical trials in patients with type 2 diabetes, ATX-304 improved glycemia, insulin sensitivity, and cardiac function as an add-on to metformin.
Β
The mechanistic breadth of ATX-304 makes it interesting for several goals at once: metabolic optimization, fatty liver disease, organ protection under stress, and physical performance. Clinical data exist for diabetes and the cardiovascular system, which favorably distinguishes it from most research agents in this category.
Β
π₯ Fat metabolism (Ξ²-oxidation, liver): β
β
β
β
β
π¬ Insulin sensitivity and glucose: β
β
β
β
β
π‘οΈ Organ protection (liver, kidneys): β
β
β
β
β
β
Safety: β
β
β
ββ (clinical diabetes data; broad tissue profile requires monitoring)
β οΈ Possible sensations and side effects: well tolerated per clinical data; limited long-term data
Β
π€ Combinations (goal β stack)
π₯ Metabolic optimization β ATX-304 + SLU-PP-332
π¬ Insulin sensitivity + weight β ATX-304 + Orforglipron
β‘ Mitochondria + metabolism β ATX-304 + NAD+
| CAS number | 1261289-04-6 |
| Batch purity | 99.67 % |
Full information in our guide
https://peptideboost.ru/shop/atx-304-4g
Dear customers
We are pleased to offer you high-quality peptide products for research purposes within laboratory experiments. Any introduction of these products into the human or animal body is strictly prohibited.
Before purchasing, please carefully read our terms.
We guarantee the quality, purity, and conformity to the description of the products we provide, but their use should only be carried out by qualified specialists with the necessary knowledge and equipment for safe handling.
Our products are not intended for use as dietary supplements, medicines, food products, or cosmetics. Peptide Boost products should not be mislabeled, used, or designated as such. Purpose and use are strictly limited to scientific research.
Information on our website is for educational and informational purposes only. We make no claims about the ability to treat or prevent diseases with our products.
Thank you for your understanding and we wish you success!
Any questions left?
Leave your email and we will definitely call you back to advise you on the product
