CJC-1295 DAC is a synthetic 29–amino acid analog of growth hormone–releasing hormone (GHRH) equipped with Drug Affinity Complex—a chemical modification enabling reversible binding to serum albumin. This binding radically extends half-life: instead of 7–10 minutes for native GHRH, the molecule remains active for 6–8 days, allowing weekly or biweekly injection schedules. The mechanism is binding to the GHRH receptor on pituitary somatotrophs and stimulation of pulsatile growth hormone secretion in a physiologically driven rhythm.
Prolonged pituitary stimulation leads to sustained elevation of GH and IGF-1. In phase I clinical trials, a single CJC-1295 DAC injection produced significant increases in both markers persisting 6–11 days. Under sustained IGF-1, protein synthesis in muscle, fatty acid oxidation, and reparative processes in connective tissue are activated; with long-term use this is associated with gains in lean mass, reduction of fat depots, and improved recovery.
Compared with the version without DAC, the key difference is secretion pattern: CJC-1295 without DAC produces an acute physiological GH surge, convenient in combination with ghrelin mimetics, whereas the DAC version provides a constant background elevation—a pattern closest to recombinant GH use. Adverse events in studies included transient skin flushing, warmth sensation, and moderate fluid retention—a typical profile for the GH stimulator class.
💪 GH/IGF-1 stimulation (clinically confirmed): ★★★★★
🏋️ Lean mass and recomposition: ★★★★☆
🔥 Fat metabolism: ★★★★☆
✅ Safety: ★★★☆☆ (GH class requires IGF-1 monitoring)
⚠️ Possible sensations and side effects: fluid retention, limb numbness, injection-site redness
🤝 Combinations (goal → stack)
💪 GH axis + ghrelin → CJC-1295 DAC + Ipamorelin
🏁 Recomposition + metabolism → CJC-1295 DAC + 5-Amino-1MQ
🔧 Recovery + GH → CJC-1295 DAC + BPC-157
| CAS number | CAS 446262-90-4 |
| Batch purity |
Full information in our guide
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