DSIP (delta sleep-inducing peptide) is a nonapeptide, Trp-Ala-Gly-Gly-Asp-Ala-Ser-Gly-Glu, and one of the most enigmatic endogenous peptides: despite 50 years of study, its gene precursor and a high-affinity receptor in the human genome remain unidentified, making DSIP an "orphan peptide." It was originally isolated from the cerebrovenous blood of rabbits during electrically induced slow-wave sleep. When administered intravenously, subcutaneously, or intracerebroventricularly in rodents and cats, it reliably increased the proportion of delta sleep; in humans, morning and evening infusions increased total sleep duration.
DSIP's neuromodulatory profile extends well beyond sleep: it potentiates GABAergic transmission and blocks NMDA receptors, which explains its anxiolytic and antinociceptive effects. Along the neuroendocrine axis, DSIP lowers basal corticotropin levels and blocks its release in response to CRF — in other words, it dampens HPA hyperactivation under chronic stress. In parallel, it stimulates LH and GH release, making the profile especially relevant for recovery protocols in athletes: deep sleep + reduced cortisol + GH stimulation — three conditions met simultaneously with DSIP use. Antioxidant and cytoprotective activity has also been described.
DSIP follows a circadian rhythm in plasma: peak in the late afternoon, minimum in the early morning — consistent with its role in the transition to slow-wave sleep. Clinical data are limited to small trials in insomnia and narcolepsy with mixed results; however, in the context of recovery and longevity protocols, the combined profile (sleep + cortisol + GH) makes the molecule functionally interesting.
🌙 Slow-wave (delta) sleep: ★★★★☆
🧘 Cortisol reduction and HPA axis: ★★★★☆
⚡ GH release and recovery: ★★★☆☆
✅ Safety: ★★★★☆ (endogenous peptide; described as well tolerated)
⚠️ Possible sensations and side effects: drowsiness; blood pressure reduction in some users; individual variation
🤝 Combinations (goal → stack)
🌙 Sleep + circadian rhythm → DSIP + Epitalon
🧘 Recovery + cortisol → DSIP + BPC-157
⚡ GH + nighttime recovery → DSIP + Ipamorelin
| CAS Number | 62568-57-4 |
| Batch Purity | 99.12 % |
Full information in our guide
https://peptideboost.club/guide/dsip
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