Glutathione is the tripeptide Glu-Cys-Gly, the most abundant intracellular antioxidant in the human body, functioning simultaneously as a redox buffer, detoxification agent, and immunomodulator. In mitochondria and the cytoplasm, it maintains the cell's reducing potential, neutralizing reactive oxygen species (ROS) via glutathione peroxidase and participating in the regeneration of other antioxidants — ascorbate and tocopherol — back to their active forms. Glutathione levels in tissues decline with age and under chronic stress, infections, chemical burden, and systemic inflammation — precisely in these states, replenishing its stores is most justified.
In the liver, glutathione is a central participant in phase II detoxification: glutathione S-transferases conjugate it with electrophilic metabolites of drugs, toxins, and endogenous compounds, converting them to water-soluble forms for renal excretion. Under high medication load, alcohol, or toxic liver injury, this system experiences substrate deficit, and direct glutathione administration replenishes it. In parallel, glutathione participates in immune response regulation: at adequate levels, T lymphocytes retain proliferative potential and cytotoxic function, whereas deficiency shifts the immune phenotype toward chronic low-grade inflammation.
Intravenous administration remains the most bioavailable format — oral glutathione is actively degraded in the intestine. With systemic administration, plasma concentrations reach therapeutically meaningful levels, providing detoxification, neuroprotection, and support of melanin metabolism — the latter underlies use in aesthetic medicine for skin tone evening. The 1500 mg volume is designed for a full course protocol with sustained systemic effect.
🛡️ Antioxidant protection (redox buffer): ★★★★★
🧬 Liver detoxification (phase II): ★★★★★
🔥 Immune support and anti-inflammatory background: ★★★★☆
✅ Safety: ★★★★☆ (endogenous molecule; infusion rate should be controlled with IV administration)
⚠️ Possible sensations and side effects: with rapid IV — mild burning, dizziness; with slow infusion usually neutral
🤝 Combinations (goal → stack)
🛡️ Antioxidant protocol → Glutathione + NAD+
🧬 Detox + liver → Glutathione + HEP-1
✨ Skin + systemic protection → Glutathione + GHK-Cu
| CAS Number | 70-18-8 |
| Batch Purity |
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