HEP-1 (Human Ezrin Peptide 1) is a synthetic 14-amino-acid peptide reproducing amino acids 324–337 of the ezrin protein — a cytoskeletal protein linking the cell membrane to the actin cytoskeleton and participating in T-cell immune synapses. This region, called the Hep receptor, forms a double antiparallel alpha helix with alternating charged residues — a structure that plays a role in activation of the adaptive immune response. By binding to this ezrin region, HEP-1 modulates conformational changes in the protein and initiates downstream signaling events that enhance immune activity.
As an immunomodulator, HEP-1 enhances adaptive immunity through B- and T-cell arms: it increases antibody titers after hepatitis B vaccination, strengthens lymphocyte proliferative response, and normalizes subpopulation ratios in immunodeficient states. However, the molecule is not a full immunostimulant — it is more accurately described as an immunoregulator: it "brings up" a reduced immune response to normal without causing hyperactivation in a normally functioning system. Hepatoprotective potential is also described through protection of hepatocytes from toxic load and reduction of inflammatory cytokines in liver tissue.
In clinical development, HEP-1 (trade name Gepon) was used in viral infections, immunodeficient states, and after toxic burden, demonstrating a favorable tolerability profile. A clinical protocol for COVID-19 (NCT04627233) was initiated, evaluating immunomodulatory effect in severe infectious conditions. The evidence base remains predominantly observational and requires additional RCTs; however, the molecular mechanism and application experience are described in considerable detail.
🛡️ Immunomodulation (B and T cells): ★★★★☆
🧬 Hepatoprotection and detoxification: ★★★☆☆
🔥 Antiviral and anti-inflammatory background: ★★★☆☆
✅ Safety: ★★★★☆ (described as a safe immunomodulator in available clinical data)
⚠️ Possible sensations and side effects: well tolerated per available data; adverse events rarely reported
🤝 Combinations (goal → stack)
🛡️ Immune background + detox → HEP-1 + Glutathione
🛡️ Immune defense + infection → HEP-1 + Thymosin Alpha 1
🧬 Liver + systemic support → HEP-1 + BPC-157
| CAS Number | 174641-44-2 |
| Batch Purity | 98.63 % |
Full information in our guide
https://peptideboost.club/guide/hep-1
Dear customers
We are pleased to offer you high-quality peptide products for research purposes within laboratory experiments. Any introduction of these products into the human or animal body is strictly prohibited.
Before purchasing, please carefully read our terms.
We guarantee the quality, purity, and conformity to the description of the products we provide, but their use should only be carried out by qualified specialists with the necessary knowledge and equipment for safe handling.
Our products are not intended for use as dietary supplements, medicines, food products, or cosmetics. Peptide Boost products should not be mislabeled, used, or designated as such. Purpose and use are strictly limited to scientific research.
Information on our website is for educational and informational purposes only. We make no claims about the ability to treat or prevent diseases with our products.
Thank you for your understanding and we wish you success!
Any questions left?
Leave your email and we will definitely call you back to advise you on the product
