PTP-20 (palmitoyl tetrapeptide-20) is a biomimetic peptide developed as an Ξ±-MSH agonist for gray hair applications. Unlike melanotan peptides designed for systemic administration, PTP-20 is formulated for topical use: the palmitoyl group at the N-terminus enables penetration through the lipid barrier of the skin and stratum corneum into the hair follicle. The molecule binds MC1R in dermal papilla cells of the follicle, triggering cAMP-dependent activation of MITF and tyrosinase β reproducing the physiological melanogenic signal at the site of hair pigment synthesis.
Concurrently, PTP-20 activates sirtuin SIRT1 β an NADβΊ-dependent regulator of cellular stress and aging in the follicle β and reduces intracellular HβOβ levels by 30% through enhanced catalase expression. This is fundamentally important: hydrogen peroxide accumulating with age in follicle cells is the primary chemical agent of hair graying β it oxidizes melanin from within and destroys melanocytes. Reducing oxidative load thus targets two links in graying pathogenesis simultaneously: deficient melanogenic signaling and oxidative pigment destruction.
In a clinical pilot on 15 men with premature graying, daily application of a lotion with 10 ppm PTP-20 for 3 months showed increased expression of MC1R, TRP-1, and Melan-A in plucked hair biopsies β direct evidence of restored melanocyte activity. The effect requires prolonged and regular use: restoring hair pigmentation is a slow biological process requiring several months of consistent application.
π Follicular melanogenesis (MC1R, topical): β
β
β
β
β
π‘οΈ Follicular antioxidant protection (catalase, HβOβ): β
β
β
β
β
β³ Graying slowdown (clinical pilot): β
β
β
ββ
β
Safety: β
β
β
β
β
(topical use; no systemic risks reported)
β οΈ Possible sensations and side effects: local irritation with individual sensitivity; no systemic effects
π€ Combinations (goal β stack)
π Pigmentation + follicle matrix β PTP-20 + GHK-Cu
π Graying + melanogenic signal β PTP-20 + MT1
π Comprehensive hair program β PTP-20 + Capixyl
Full information in our guide
https://peptideboost.club/guide/ptp-20Dear customers
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