SLU-PP-332 is a synthetic pan-agonist of estrogen-related receptors ERRΞ±, ERRΞ², and ERRΞ³, originally identified by the Burris group at Washington University as an "exercise mimetic" β a molecule reproducing aerobic exercise cellular programs without physical exertion. ERRs are nuclear receptors that do not bind estrogens but control transcription of hundreds of genes involved in mitochondrial biogenesis and oxidative metabolism. SLU-PP-332 binds ERRΞ± with EC50 around 98 nM and triggers expression of PGC-1Ξ± β the master regulator of mitochondrial biogenesis, GLUT4 for glucose uptake, and the ESRRA-dependent gene set characteristic of acute aerobic exercise. In essence, the molecule tricks the cell into thinking the organism is running.
The preclinical profile is compelling: in mice, SLU-PP-332 significantly increased the proportion of fast oxidative type IIa muscle fibers, improved running endurance, and reduced fat mass without dietary restriction. In an aging rodent model, the peptide restored kidney mitochondrial function to 60% of trained animal levels. In metabolic syndrome, SLU-PP-332 therapy improved insulin sensitivity, reduced hepatic fat, and normalized inflammatory markers β via an AMPK-independent ERR pathway, distinguishing it from metformin and most metabolic agents. DDIT4 activation is considered an additional mechanism linking the ERR axis to stress management and energy homeostasis.
Important context: the molecule has a short half-life (~2 hours), limiting effect duration with single administration. Analogs with improved pharmacokinetics are under development (SLU-PP-915). Human data are not yet available β the entire evidence base is preclinical, requiring measured expectations when extrapolating to humans.
β‘ Mitochondrial biogenesis (PGC-1Ξ±, ERRΞ±): β
β
β
β
β
π Endurance and oxidative fibers (preclinical): β
β
β
β
β
π₯ Fat metabolism and insulin sensitivity: β
β
β
β
β
β
Safety: β
β
β
ββ (no human data; preclinical without prominent toxic signals)
β οΈ Possible sensations and side effects: neutral in preclinical studies; short TΒ½ limits single-dose effect
π€ Combinations (goal β stack)
β‘ Mitochondria + energetics β SLU-PP-332 + NAD+
ποΈ Exercise + metabolism β SLU-PP-332 + BAM15
π₯ Fat metabolism + endurance β SLU-PP-332 + Retatrutide
| CAS number | 303760-60-3 |
| Batch purity | 99.96 % |
Full information in our guide
https://peptideboost.club/guide/slu-pp-332
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