Survodutide (BI 456906) is a dual agonist of GLP-1 and glucagon (GCGR) receptors, developed by Boehringer Ingelheim. Architecturally it is closer to retatrutide than to tirzepatide: where tirzepatide combines GLP-1 and GIP, survodutide replaces GIP with a glucagon component. GCGR activation enhances thermogenesis in brown adipose tissue and hepatic β-oxidation of fat, increasing caloric expenditure — adding the expenditure side of the equation to intake reduction via GLP-1. Combined, this enables more significant weight reduction than GLP-1 mono-agonism at comparable doses.
In Phase II for obesity, survodutide showed body weight reduction up to 18.7% and HbA1c reduction to −1.71% — data exceeding semaglutide for weight response and comparable for glycemia. In a meta-analysis, longer interventions (>16 weeks) and higher doses (>2 mg/week) were associated with substantially greater weight and waist circumference reduction. Parallel research targets MASH (metabolic steatohepatitis): in this direction, survodutide demonstrated significant hepatic fat reduction and improved fibrosis markers, explained by glucagon-driven activation of mitochondrial fat oxidation directly in hepatocytes.
The adverse event profile is analogous to the GLP-1 class: nausea, diarrhea, vomiting, manageable with slow titration. Specific to the GCGR component — risk of glycemic instability when used with insulin and potential cardiovascular limitations, being clarified in ongoing Phase III trials.
⚖️ Weight reduction (GLP-1 + GCGR): ★★★★★
🔥 Thermogenesis and fat metabolism (GCGR): ★★★★☆
🍺 MASH / steatohepatitis (hepatic fat, fibrosis): ★★★★☆
✅ Safety: ★★★☆☆ (Phase III; GI profile of the class; glycemic monitoring in diabetes)
⚠️ Possible sensations and side effects: nausea, vomiting; slow titration mandatory
🤝 Combinations (goal → stack)
⚖️ Weight + amylin → Survodutide + Cagrilintide
🔥 Metabolism + mitochondria → Survodutide + SLU-PP-332
💪 Weight + muscle → Survodutide + IGF-1 LR3
| CAS number | 2805997-46-8 |
| Batch purity | 99.13 % |
Full information in our guide
https://peptideboost.club/guide/survodutide
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